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Confocal Modules

Research-based Modules

The following modules are based on the presenting professor's ongoing research.

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Epithelial Cells and Cell Migration, Dr. Rafael Garcia-Mata

• Cancer cells are able to move around the body to metastasize
• Most cancers begin in epithelial cells
• Epithelial cells stick together through tight junctionsÌý

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Atypical Centrioles and Reproduction, Dr. Tomer Avidor-Reiss

• Two centrioles are necessary for cells to divide
  
• Sperm cells contain one typical centriole and one atypical centriole, ova contain none
• Atypical centrioles from sperm cells are likely necessary for reproduction

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Specialized Epithelia of the Gut and their Disorders,ÌýDr. Scott W. Crawley

• Specialized gut epithelial cells mediate nutrient uptake
• These cells build sophisticated protrusions on their surface for this purpose
• Malformation of these protrusions cause severe gastrointestinal disease

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ÌýCancer Cells and the Mitotic Checkpoint, Dr. Song-Tao Liu

• Microscopy can be used to make a movie of cell division
• Diseases such as birth defects and cancer can originate from abnormal cell division
• Specific proteins contribute to faithful chromosome segregation

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Fission Yeast and the Molecular Mechanism of Cytokinesis, Dr. Qian Chen

• Something in the cell signals the beginning of cytokinesis
• Force is needed to split cells
• Myosin and actin are important proteins in cytokinesis

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Mapping Information Flow in the C. elegans Nervous System,ÌýDr. Bruce Bamber

• The nervous system is responsible for sensory motor processing
• C. elegans nervous system (302 neurons) is much simpler than human brain (86 billion neurons)
• Mapping the nervous system of c. elegans can add to our understanding of sensory motor processing

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ÌýOhio Science Standards

Each of the following modules start off with a basic concept. As some subjects are re-examined in further detail in high school science classes, the same modules can be used for various grade levels by adding or subtracting information.

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Cells have particular structures related to their function

• Instrument: Confocal Light Microscope
• Grade level/class: Grade 6, High School BiologyÌý

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Reproduction is necessary for the continuation of every species

• Instrument: Confocal Light Microscope
• Grade level/class: Grade 8, High School Biology

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Cells go through a process called mitosis

• Instrument: Confocal Light Microscope
• Grade level/class: Grade 6, High School Biology

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Pictured: An in-person Confocal SCOPE session set-up

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